|
Cats are a ubiquitous source of allergens, yet, paradoxically,
high exposure to cat allergens can cause tolerance. In this
issue, we Focus On...Fel d 1,
and cover recent data on Fel d 1 structure and targeting Fel
d 1 specific T cell responses - data to be presented at the
American Academy of Allergy Asthma and Immunology (AAAAI)
annual meeting, this week in Philadelphia.
In response to several enquiries, we discuss phthalates
and endotoxin, or lack thereof, in DUSTREAM™
collectors. We also provide details of our Vial Replacement
Program which enables ELISA kit standards to be replaced free
of charge with the new Universal Allergen Standard.
MARIA™ for allergen
detection and allergen-specific IgE will be the theme of Indoor
Biotechnologies exhibit at AAAAI. Please visit the exhibit
for a demonstration of this powerful technology and how it
can help your research projects.
¡Se habla español! Para todos
nuestros amigos de habla hispana, Indoor Biotechnologies ha
recibido el permiso para reproducir el capítulo de las Dras.
Anna Pomés y Mayte Villalba sobre "Alérgenos" del libro de
texto Tratado de Alergología, producido bajo los auspicios
de la Sociedad Española de Alergia e Inmunología Clínica...ver
detalles más abajo!
Finally, our training course on indoor allergens is scheduled
for September in Charlottesville. We look forward to seeing
you at AAAAI in Philadelphia.
| INBIO
at AAAAI , Philadelphia, March 14-18 |
 |
|
Please join us at Exhibit 219 for further information
about our products and services:
- Multiplex arrays for indoor allergens (MARIA™)
on the Luminex xMAP® system
- DUSTREAM™ environmental samplers
- LoTox™ low endotoxin purified allergens
- ELISA products, rapid tests
Join us for a demonstration of MARIA™ technology,
which enables 8 allergens to be measured in a single
test - one test, multiple assays!
Scientists from INDOOR Biotechnologies have several
oral and poster
presentations at AAAAI.
|
| MARIA™
Allergen Arrays |
|
|
MARIA™
- Multiplex ARrays for Indoor Allergens using Luminex
xMAP® technology
MARIA™ represents the next generation of ELISA
and combines Indoor Biotechnologies allergen- specific
monoclonal antibodies with the power of Luminex xMAP®
technology to measure eight allergens at once in a single
test. MARIA™ provides improved assay performance
(increased sensitivity, accuracy and precision) in a
high throughput system with substantial time and cost
savings.
Customers can choose from two kits, each containing
pre-mixed microspheres, as follows:
- 5-plex: Der p 1, Der
f 1, Mite Group 2, Fel d 1, Can f 1 (Product Code
MRA-P5)
- 8-plex: Der p 1,
Der f 1, Mite Group 2, Fel d 1, Can f 1, Rat n 1,
Mus m 1, Bla g 2 (MRA-P8)
Custom combinations of bead sets are available.
For a limited time, custom 5-plex arrays will be the
same price as our standard 5-plex. Standard discounts
(15%) are applied to orders of five or more kits.
MARIA™ kits and services are available exclusively
through Indoor Biotechnologies. For full details, see:
www.inbio.com/maria
|
| Allergen
Standards - Vial Replacement Program |
|
|
Indoor
Biotechnologies recently introduced a Universal Allergen
Standard (UAS) that contains eight purified natural
allergens from dust mite, cat, dog, rat, mouse and cockroach
[UAS
pdf]. The UAS is designed for use in both ELISA
and MARIA™. From January 2008, the UAS is provided
in ELISA and MARIA™ kits.
To
assist customers in changing to the UAS, Indoor Biotechnologies
has implemented a free vial replacement program. Under
this program, vials of ELISA allergen standards in ELISA
kits that were purchased after July
1, 2007 will be replaced free of charge with
one vial of the UAS for each ELISA kit purchased.
To
take advantage of this offer customers should provide:
invoice or other documentation of ELISA kit purchase;
number of ELISA kits purchased; ELISA kit product codes;
and number of replacement vials being requested. US
customers should contact: mail@inbio.com
: other customers should contact our UK office at:
info@indoorbiotech.co.uk.
|
| DUSTREAM™,
Phthalates & Endotoxin |
|
|
DUSTREAM™ collectors are essentially phthalate
and endotoxin free. In response to customer enquiries,
our plastics company has checked with the three manufacturers
whose products are used in DUSTREAM™: DOW Chemical,
Clariant Corp., and Basell Polyolefins. DOW and Clariant
do not use phthalates in their manufacturing processes.
The phthalate concentration of Basell resins is less
than 25ppm: in contrast, plastics that require phthalate
plasticizers contain up to 500,000ppm phthalates. Documents
are on file to confirm these specifications. We also
have data indicating that the surface endotoxin levels
on the collectors are undetectable.
Based on these data, INDOOR Biotechnologies believes
that DUSTREAM™ collectors can be reliably used
for environmental sampling to determine exposures to
phthalates and endotoxin.
|
| INBIO
Training Course on Health Effects of Indoor Allergens...September
08 |
|
|
Need to know more about indoor allergens, allergic
disease and environmental exposure assessment? We will
again be holding our successful training course in Charlottesville,
September 8-10, 2008. Join us for the course on "Health
Effects of Indoor allergens, Molds and Endotoxin: Theory
and Practice". The conference includes a distinguished
list of invited speakers:
Elizabeth Matsui MD:
Allergens and asthma in inner cities
Matt Perzanowski PhD: Endotoxins
in allergic disease - a plus or minus?
Herman Mitchell MD: Environmental
risk factors for asthma and their control
This year the program features multiplex array technology
for allergen detection (MARIA™). Participants
will be the first to gain hands-on experience of this
powerful technology for allergen exposure assessment.
The course provides an excellent opportunity to learn
in a relaxed and informal setting. Charlottesville in
September is delightful and we are an easy two hours
drive from Washington DC.
The conference is limited to 40 participants. Please
register to reserve your place(s) as soon as possible.
INBIO Training Course - Preliminary
Announcement
|
| ¡Alérgenos
en español! |
|
|
Acaba de aparecer un compendio del conocimiento actual
sobre enfermedades alérgicas en español: el Tratado
de Alergología. Esta obra surgió como una iniciativa
de la Junta Directiva de la Sociedad Española de Alergia
e Inmunología Clínica, con la intención de agrupar y
reflejar, en una única obra, el conocimiento actual
en este campo y facilitar su estudio. La obra, editada
por los Drs. Antonio Peláez e Ignacio J. Dávila, ha
sido patrocinada por Glaxo-SmithKline y publicada por
la editorial Ergon. Tal como los editores mencionan
en el prólogo a la primera edición, el Tratado "viene
a llenar una laguna existente en la literatura médica
en español". A modo de introducción al Tratado de Alergología,
y con el permiso de la SEAIC, GSK y Ergon, presentamos
el primer capítulo sobre Alérgenos (pulsar).
|
|
|
Focus
On...Fel d 1
|
|
|
|
-the
major cat allergen, a thermostable 35kDa tetrameric
glycoprotein. Read
more about the structure and function of Fel d 1,
our new recombinant de-glycosylated Fel d 1 expressed
in Pichia pastoris, and targeting Fel d 1 to
antigen presenting cells using anti-CD64-Fel d 1 construct.
Two papers on these topics will be presented at AAAAI:
Wuenschmann et al, JACI 121 (2): S214 (Abst #821) Hulse
et al, JACI 121 (2): S305 (Abst #559)
Product
Information
|
|
AIHCE in Minneapolis. 
EAACI in Barcelona 
New product line for 2008! Indoor Biotechnologies is delighted to
launch our Multiplex ARray for Indoor Allergens (MARIA™)
kits and services - the next generation of ELISA for allergen
exposure assessment. 
